Thermoplastic elastomers for microfluidics: Towards a high-throughput fabrication method of multilayered microfluidic devices

Download
  1. Get@NRC: Thermoplastic elastomers for microfluidics: Towards a high-throughput fabrication method of multilayered microfluidic devices (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1039/c1lc20251k
AuthorSearch for: ; Search for: ; Search for:
TypeArticle
Journal titleLab on a Chip - Miniaturisation for Chemistry and Biology
ISSN1473-0197
Volume11
Issue18
Pages31933196; # of pages: 4
Subjectdimeticone; elastomer; article; biocompatibility; chemical binding; microfluidics; microtechnology; pressure; priority journal; room temperature; viscoelasticity
AbstractMultilayer soft lithography of polydimethylsiloxane (PDMS) is a well-known method for the fabrication of complex fluidic functions. With advantages and drawbacks, this technique allows fabrication of valves, pumps and micro-mixers. However, the process is inadequate for industrial applications. Here, we report a rapid prototyping technique for the fabrication of multilayer microfluidic devices, using a different and promising class of polymers. Using styrenic thermoplastic elastomers (TPE), we demonstrate a rapid technique for the fabrication and assembly of pneumatically driven valves in a multilayer microfluidic device made completely from thermoplastics. This material solution is transparent, biocompatible and as flexible as PDMS, and has high throughput thermoforming processing characteristics. We established a proof of principle for valving and mixing with three different grades of TPE using an SU-8 master mold. Specific viscoelastic properties of each grade allow us to report enhanced bonding capabilities from room temperature bonding to free pressure thermally assisted bonding. In terms of microfabrication, beyond classically embossing means, we demonstrate a high-throughput thermoforming method, where TPE molding experiments have been carried out without applied pressure and vacuum assistance within an overall cycle time of 180 s. The quality of the obtained thermoplastic systems show robust behavior and an opening/closing frequency of 5 Hz. © 2011 The Royal Society of Chemistry.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Industrial Materials Institute (IMI-IMI)
Peer reviewedYes
NPARC number21271412
Export citationExport as RIS
Report a correctionReport a correction
Record identifierf60d3832-12ed-4ac3-b496-e84d9181523c
Record created2014-03-24
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)