The structure of chloramphenicol

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Journal titleActa Crystallographica
Pages13601363; # of pages: 4
AbstractThe structure of chloramphenicol, an important broadspectrum antibiotic, has been solved by direct methods with X-ray diffraction data collected using Mo K-alpha radiation. The crystals are orthorhombic, with space group C2221, and the structure has been refined by Fourier and least-square techniques to an R of 0.069 for 940 observed reflections. The side chain exists in the 'alicyclic' form, stabilized by hydrogen bonding between the hydroxyl groups. The dichloroacetamido moiety is folded back over the phenyl ring.
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AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Chemical Process and Environmental Technology
Peer reviewedYes
NRC number52307
NPARC number16296145
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Record identifierf8615cdc-ac51-4d4c-bb0f-74c5f3fc915e
Record created2010-11-04
Record modified2016-05-09
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