Development of a composite material phantom mimicking the magnetic resonance parameters of the neonatal brain at 3.0 Tesla

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DOIResolve DOI: http://doi.org/10.1097/RLI.0b013e3180ca70e4
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TypeArticle
Journal titleInvestigative Radiology
ISSN1536-0210
Volume42
Issue11
Pages739746; # of pages: 8
Subjectphantom; magnetic resonance imaging; neonatal brain; polyvinyl alcohol cryogel; 3.0 T
AbstractObjective: Development of a composite material phantom, comprised of polyvinyl alcohol cryogel (PVA-C) and an agarose additive, to effectively mimic the magnetic resonance relaxation times (T1 and T2) of neonatal white matter (WM) and gray matter (GM) at 3.0 T. Materials and Methods: Samples of PVA-C with and without agarose were prepared with 1 cycle of freezing/thawing. Measurements of T1 and T2, at 3.0 T, were performed on the samples at temperatures ranging from 20°C to 40°C. Results: A sample temperature of 40°C was required to achieve a T1 value sufficiently long to represent neonatal WM. At this temperature, neonatal WM relaxation times required 3% PVA-C with 0.3% agarose, whereas gray matter relaxation times required 8% PVA-C with 1.4% agarose. Conclusions: By adjusting the sample temperature, polyvinyl alcohol concentration, and agarose concentration, the relaxation times of neonatal brain tissues can be obtained using this composite material.
Publication date
LanguageEnglish
AffiliationNRC Industrial Materials Institute; National Research Council Canada
Peer reviewedYes
NPARC number21274311
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Record identifierf8774c58-cc54-4ac2-a923-abb7036d548e
Record created2015-03-09
Record modified2016-05-09
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