Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta-catenin protein synthesis

Download
  1. Get@NRC: Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta-catenin protein synthesis (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1038/sj.onc.1210667
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleOncogene
Volume27
Pages755762; # of pages: 8
AbstractEukaryotic initiation factor 6 (eIF6), an essential protein important in ribosome biosynthesis and assembly, was identified as an interacting partner of the β-catenin C terminus in the yeast two-hybrid assay. Independent studies identified Drosophila eIF6 (DeIF6) in a genetic screen designed to detect new genes involved in the regulation of the Wnt/Wg (wingless) pathway. Ectopic expression of DeIF6 in wing discs results in a Wg phenotype. Expression of eIF6 in adenomatous polyposis coli (APC)-mutant colon cancer cells, which express high levels of active β-catenin, showed that eIF6 selectively inhibits the Wnt pathway at the level of β-catenin protein independently of proteasomal degradation. Incorporation of radiolabeled amino acids into β-catenin was selectively decreased in cells that overexpressed eIF6. A similar inverse relationship of the two proteins was observed in the APCmin/+ mouse intestine, in which β-catenin levels are very high. Taken together these data reveal a link between eIF6 and Wnt signaling, perhaps at the level of ribosome recycling on β-catenin mRNA
Publication date
Publishernature publishing group
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NRC number1775
NPARC number3538441
Export citationExport as RIS
Report a correctionReport a correction
Record identifierf932caea-975c-46d6-88bc-6fd222fefe04
Record created2009-03-01
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)