A new approach towards controlled synthesis of multifunctional coreshell nano-architectures: luminescent and superparamagnetic

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DOIResolve DOI: http://doi.org/10.1166/jnn.2006.622
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TypeArticle
Journal titleJournal of Nanoscience and Nanotechnology
Volume6
Pages36773684; # of pages: 8
SubjectCore-Shell; Luminescent; Nanoparticles; Silica; Superparamagnetic
AbstractWe have developed a two-step method for synthesis of multifunctional core-shell nanoparticles with an improved structure as compared with those prepared by traditional methods used independently. The nanoparticles comprise a superparamagnetic core, an inner insulating dye-free silica shell, an outer luminescent silica shell encapsulating thousands of dye molecules and a functionalizeable surface. The innovative insertion of the isolating silica shell benefits the nanoparticles' architecture in two ways. Firstly, by keeping the dye molecules away from the magnetic core, the silica shell prevents dye luminescence quenching. Secondly, the non-magnetic shell decreases magnetic interparticle coupling, which, by reducing aggregation and preventing agglomeration, facilitates the formation of the high-quality luminescent shell in the second step of the process. The final nanoparticles being both superparamagnetic and luminescent have a great potential for theranostic applications such as ultra-sensitive detection, and in-vitro and in-vivo imaging.
Publication date
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
NPARC number12328834
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Record identifierf96f5676-6243-4cae-8c08-d37cf06459cd
Record created2009-09-10
Record modified2016-05-09
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