Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides

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DOIResolve DOI: http://doi.org/10.1016/j.bmcl.2008.01.061
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TypeArticle
Journal titleBioorganic & Medicinal Chemistry Letters
Volume18
Issue5
Pages16631667; # of pages: 5
Subjectpha; synthesis
AbstractA series of 3,5-dialkoxy-4-hydroxycinnamamides 6 and 7 was synthesized, and their antioxidant activity was assessed using the thiobarbituric acid reactive substance (TBARS) assay. Interestingly, cinnamamides with longer alkoxy groups on the C-3 and C-5 positions display enhanced inhibition, and most of the compounds in the series tested exhibit excellent lipid peroxidation inhibitory activities. Some cinamamides bearing hexyloxy or 2,6-di-tert-butyl-4-methyl phenol groups have submicromolar inhibitory activities
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedNo
NRC number49571
NPARC number3539059
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Record identifierf9902e95-4960-4bd4-b973-7bfe8e9fcb28
Record created2009-03-01
Record modified2016-05-09
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