CD46, a primate-specific receptor for measles virus

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TypeArticle
Journal titleTrends Microbiol
Trends in microbiology
ISSN0966842
Volume2
Issue9
Pages3128; # of pages: 305
SubjectAmino Acid Sequence; Animals; Antigens, CD; Antigens, CD46; Disease Susceptibility; Epitopes; Humans; Measles; Measles virus; Membrane Glycoproteins; Molecular Sequence Data; Primates
AbstractMeasles virus normally infects only primate cells. The receptor for measles virus has recently been shown to be the complement regulator CD46, also known as membrane cofactor protein. Transfection of rodent cells with human CD46 renders them susceptible to the virus, suggesting that transgenic animals may prove useful for testing antiviral agents and vaccines.
Publication date
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedNo
NPARC number12330804
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Record identifierf9e28c42-84ea-4a6b-9aff-5e5730fb6b47
Record created2009-09-10
Record modified2016-05-09
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