Supramolecular catalysis of H/D exchange in pyruvate by macrocyclic polyamines involving a reactive iminium intermediate

Download
  1. Get@NRC: Supramolecular catalysis of H/D exchange in pyruvate by macrocyclic polyamines involving a reactive iminium intermediate (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1039/a700937b
AuthorSearch for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleJournal of the Chemical Society, Perkin Transactions 2
Issue10
Pages20732081; # of pages: 9
AbstractThe activity of a series of macrocyclic polyamines as catalysts for proton exchange has been investigated. Structural and physico-chemical studies demonstrate the ability of these receptors to recognize pyruvate, form a covalent iminium intermediate and catalyse H/D exchange at the CH3 position. The reaction follows Michaelis-Menten kinetics with a rate enhancement higher than 4.8[times]105 (kcat/kuncat). The process also represents a potential entry into the catalysis of aldol condensation reactions.
Publication date
LanguageEnglish
Peer reviewedNo
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NRC number596
NPARC number12328534
Export citationExport as RIS
Report a correctionReport a correction
Record identifierfa157558-f41b-4429-9203-80c38b305724
Record created2009-09-10
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)