Immunization with N-propionyl polysialic acid–KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci

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DOIResolve DOI: http://doi.org/10.1007/s00262-011-1083-6
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TypeArticle
Journal titleCancer Immunology, Immunotherapy
ISSN0340-7004
1432-0851
Volume61
Issue1
Pages918; # of pages: 10
SubjectSmall cell lung cancer; Minimal residual disease; Polysialic acid
AbstractPolysialic acid (polySA) is a polymer side chain bound to the neural cell adhesion molecule that is extensively expressed on the surface of small cell lung cancer (SCLC) cells. In our previous study, a robust antibody response was noted in patients with SCLC after vaccination with 30 μg of keyhole limpet hemocyanin (KLH)-conjugated N-propionylated (NP-) polySA, but peripheral neuropathy and ataxia were detected in several vaccinated patients. The objectives of the current trial were to establish the lowest optimal dose and to confirm the safety of the induction of antibodies against polySA with the NP-polySA vaccine.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
Identifier1083
NPARC number21268351
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Record identifierfb9827d1-719a-454c-9890-8adc5042e87d
Record created2013-06-28
Record modified2016-05-09
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