¹H NMR metabolomics combined with gene expression analysis for the determination of major metabolic differences between subtypes of breast cell lines

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DOIResolve DOI: http://doi.org/10.1039/c1sc00382h
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TypeArticle
Journal titleChemical Science
Volume2
Issue11
Pages22632270; # of pages: 8
Abstract1H NMR analysis was performed on metabolic extracts from a selection of six breast cell lines, including normal-immortalized, invasive ductal carcinomas and adenocarcinomas. Metabolites with significant concentration differences between normal and cancerous cells as well as ER+ and ER- (estrogen receptor) cells were determined and their relation to the differentially expressed genes was explored. Major differences have been shown for many amino acids and this was linked to expression level changes of related genes. Observed changes in choline concentration were connected to expression level changes of the SCL44A1 transporter gene.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Information Technology
Peer reviewedNo
NPARC number18608251
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Record identifierfbb99504-01e9-42fb-b8d0-e45299071f4b
Record created2011-09-21
Record modified2016-05-09
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