Virulence comparison in mice of distinct isolates of type A Francisella tularensis

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TypeArticle
Journal titleMicrob.Pathog.
Volume40
Issue3
Pages133138; # of pages: 6
Subjectbacterial; Canada; DIFFERENCE; INFECTION; Mice; STRAIN; STRAINS; Virulence
AbstractFrancisella tularensis subspecies tularensis (type A F. tularensis) is considered to be one of the most virulent of all bacterial pathogens. Mice are extremely susceptible to infection with this subspecies (LD(100) via various inoculation routes is <10cfu). However, it has not been established whether overt virulence differences exist amongst type A strains of F. tularensis. To this end, the present study compared the virulence of two distinct type A strains, FSC033 and SCHU S4, for naive mice and mice immunized with the live vaccine strain of the pathogen, F. tularensis LVS. One nominal isolate of SCHU S4 was found to be completely avirulent. Another isolate was highly virulent, but all examined cases appeared somewhat less virulent than FSC033. The implication of these findings for future infection and immunity studies is discussed
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biological Sciences
Peer reviewedNo
NRC numberTWINE2006
NPARC number9387453
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Record identifierfcf74a0d-4e3f-4702-9ce4-3f5cdbd1604c
Record created2009-07-10
Record modified2016-05-09
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