Pancreatic lipase inhibitory activity of monogalactosyldiacylglycerols isolated from the freshwater microalga Chlorella sorokiniana

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DOIResolve DOI: http://doi.org/10.1007/s10811-015-0558-9
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TypeArticle
Journal titleJournal of Applied Phycology
ISSN0921-8971
SubjectChlorella sorokiniana; Monogalactosyldiacylglycerol; Galactolipid; Lipase; Obesity; Microalgae
AbstractChemical investigation of the freshwater microalga Chlorella sorokiniana led to the isolation of a monogalactosyldiacylglycerol (MGDG)-rich fraction possessing dose-dependent inhibitory activity against pancreatic lipase activity. The MGDG-rich fraction contains 12 MGDGs identified by LC/HRMS analysis. Among them, three MGDGs were new compounds, namely, (2S)-1-O-(7Z,10Z-hexadecadienoyl)-2-O-(7Z,10Z,13Z-hexadecatrienoyl)-3-O-β-D-galactopyranosylglycerol (1), (2S)-1-O-linoleoyl-2-O-(7Z,10Z-hexadecadienoyl)-3-O-β-D-galactopyranosylglycerol (6), and (2S)-1-O-oleoyl-2-O-(7Z,10Z-hexadecadienoyl)-3-O-β-D-galactopyranosylglycerol (8). The major galactolipids were isolated by semipreparative HPLC and tested for their effect toward pancreatic lipase inhibitory activity. All the tested MGDGs showed significant reduction of pancreatic lipase activity indicating possible beneficial use for management of lipase-related disorders such as obesity.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; Aquatic and Crop Resource Development; Measurement Science and Standards
Peer reviewedYes
NPARC number21274792
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Record identifierfd71130c-64b5-4062-968b-9c69595f0ab3
Record created2015-04-10
Record modified2016-11-09
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