Benzofuran-Derived Cyclic β-Amino Acid Scaffold for Building a Diverse Set of Flavonoid-Like Probes and the Discovery of a Cell Motility Inhibitor

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DOIResolve DOI: http://doi.org/10.1021/ol800050g
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TypeArticle
Journal titleOrganic Letters
ISSN15237060
Volume10
Issue6
Pages11431146; # of pages: 4
AbstractWe report here a practical, enantioselective synthesis of benzofuran-derived, cyclic trans--amino acid scaffold. In two cases, tricyclic derivatives having six- and eight-membered unsaturated lactams were obtained from this versatile scaffold. To explore the biological applications, these compounds were subjected to cell-based assays, using NIH3T3 mouse cells to examine their potency as cell motility inhibitors and identified 18 as a potent cell motility inhibitor (IC50 40 M in chamber cell migration assay).
Publication date
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier18697458
NPARC number12328244
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Record identifierfe29207a-427b-49dd-8f27-4d76e6b137dd
Record created2009-09-10
Record modified2016-05-09
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