PalI domain protiens of Saccharomyces cerevisiae and Candida albicans

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DOIResolve DOI: http://doi.org/10.1016/j.micres.2011.12.005
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TypeArticle
Journal titleMicrobiological Research
Volume167
Issue7
Pages422432; # of pages: 11
SubjectPalI domain; Candida albicans; Saccharomyces cerevisiae; Environmental stress response
AbstractThe Rim9/PalI groups of proteins are members of the Sur7 family, all of which contain a signal sequence and a block of three potential trans-membrane helices. Multi-protein sequence comparisons among fungi suggest that there are two classes of Rim9/PalI proteins; longer proteins like PalI that contain a Sur7 domain and a C-terminal extension, and shorter proteins like Rim9 that contain essentially only the Sur7 domain. We have examined possible roles of the longer, PalI-like proteins of both Saccharomyces cerevisiae (Yol019w) and Candida albicans (Orf19.1510/Srd1), two species that also contain short Rim9 proteins required for alkaline-associated stress responses. Deletions of the long form genes did not create any significant stress response phenotype in either S. cerevisiae or C. albicans, nor did the deletions enhance any of the rim9 deletion effects when combined in a double mutant. Furthermore, challenges in C. albicans show RIM9 but not SRD1 is important for proper response and hyphal formation. It appears that in fungal species such as Aspergillus nidulans containing only a long-form PalI-like protein, this element functions in the process of stress response, while in fungi with both versions the response to stress function is limited to the short-form protein.
Publication date
LanguageEnglish
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedYes
NRC number50696
NPARC number20217043
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Record identifierfe6bbc1a-70e1-4125-b79b-d5fe8bb771a0
Record created2012-06-29
Record modified2016-05-09
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