Blepharocalyxins C−E, three new dimeric diarylheptanoids, and related compounds from the seeds of Alpinia blepharocalyx

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DOIResolve DOI: http://doi.org/10.1021/np000493l
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume64
Issue4
Pages491496; # of pages: 6
AbstractThree novel diarylheptanoids, blepharocalyxins C−E (5−7), together with four new (1−4) and one known (8) diarylheptanoids bearing a tetrahydropyran ring were isolated from the residual fraction of an EtOH extract of the seeds of Alpinia blepharocalyx. The structures and the stereochemistry at the chiral centers of the new diarylheptanoids were elucidated by spectroscopic techniques including 2D NMR spectroscopy. Blepharocalyxins C−E (5−7) have a novel carbon framework and are dimeric diarylheptanoids consisting of two diarylheptanoid units. Blepharocalyxin D (6) showed potent antiproliferative activity against murine colon 26-L5 carcinoma cells (ED50, 3.61 μM), while against human HT-1080 fibrosarcoma cells, blepharocalyxin E (7) showed potent activity (ED50, 9.02 μM).
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
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NPARC number21274809
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Record identifierfea70d1e-a65c-4c58-8043-2655553617b8
Record created2015-04-13
Record modified2016-05-09
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