Images of Arterial Tissues Using Catheter Swept-Source Optical Coherence Tomography

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Proceedings titleProceedings of SPIE
ConferencePhotonics North 2010, June 1-3, 2010
Pages18; # of pages: 8
Subjectbiomedical imaging; arterial tissue; plaque; optical coherence tomography; quadrature interferometer; optical fiber probe
AbstractOptical coherence tomography images of arterial samples harvested from asymptomatic pigs and from lipid-rich Watanabe heritable hyperlipidemic rabbits were acquired using a fiber catheter-based swept-source optical coherence tomography system (OCT). A quadrature Mach-Zehnder interferometer based on multi-port fiber couplers and a semiconductor optical amplifier (SOA) were employed in the swept-source optical coherence tomography system. The improvement of signal to noise ratio as a result of incorporating the SOA into the configuration translated in an increase of the penetration depth. A fiber probe ending in a fiber ball lens was developed for the arterial imaging. The images acquired by this system offer the possibility to investigate anatomical details located under the surface of the artery such as the intima, media, and adventitia layers (from lumen side) of the blood vessel wall , as well as morphological features specific to artherosclerotic plaques such as lipid pools, fibrous caps, macrophage accumulations and calcified. This report indicates that our improved catheter-based swept source OCT is a potential tool for in vivo intravascular imaging.
Publication date
AffiliationNRC Institute for Microstructural Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17400969
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Record identifierffa8145b-050f-411c-8556-500c557ee874
Record created2011-03-26
Record modified2016-05-09
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