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Selective inhibition of USP7

 
 
Affiliation:
NRC Biotechnology Research Institute; National Research Council Canada
Language:
English
Type:
Article
Published in:
Chemistry & Biology
Date:
2012
Pages :
437-438
NRCC #:
53180
NPArC #:
20548175
Abstract:
The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in this issue of Chemistry & Biology, disclose the first small-molecule inhibitor selective for USP7, which recapitulates its knockdown in cancer cells and hence demonstrates the therapeutic feasibility of USP7 inhibitors.
 
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