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Selective inhibition of USP7
; Menard, Robert
NRC Biotechnology Research Institute; National Research Council Canada
Chemistry & Biology
The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in this issue of Chemistry & Biology, disclose the first small-molecule inhibitor selective for USP7, which recapitulates its knockdown in cancer cells and hence demonstrates the therapeutic feasibility of USP7 inhibitors.