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Electrospun nanofiber membranes from polysulfones with chiral selector aimed for optical resolution

 
 
Affiliation:
NRC Institute for Chemical Process and Environmental Technology; National Research Council Canada
Language:
English
Type:
Article
Published in:
European Polymer Journal
Date:
2012
Pages :
1717-1725
NRCC #:
53103
NPArC #:
20637155
Keywords:
chiral separation; electrospray deposition; membrane; nanofiber fabric; optical resolution; permselectivity; polysulfone
Group(s):
Director R and D Office, Ottawa; Bureau du directeur R-D, Ottawa
Abstract:
Polysulfones with three types of alanyl residue, such as N-α-acetylalanine (Ac-Ala-OH), N-α-benzoylalanine (Bzo-Ala-OH), and N-α-benzyloxycarbonylalanine (Z-Ala-OH), as chiralselectors were prepared by polymer reaction. The resulting modified polysulfones showed chiroptical properties, indicating that the chiralselector residues were successfully introduced into the polysulfone. Nanofibermembranes prepared from the polymeric materials showed adsorption selectivity toward mixtures of racemic Glu, which were adopted as model racemates. Flux values for the nanofibermembranes were enhanced two to three orders of magnitude in comparison with the corresponding typical membranes, but without reduction in permselectivity. In the present study, it is shown that nanofiber is a suitable membrane form not only for molecularly imprinted membranes, but it exhibits enhanced throughput in comparison with typical dense membranes without concurrent reduction in permselectivity.
 
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