Electrospun nanofiber membranes from polysulfones with chiral selector aimed for optical resolution
; Mizushima, Hiroaki
; Yoshikawa, Masakazu
; Li, Nanwen
; Robertson, Gilles P.
Guiver, Michael D.
NRC Institute for Chemical Process and Environmental Technology; National Research Council Canada
European Polymer Journal
chiral separation; electrospray deposition; membrane; nanofiber fabric; optical resolution; permselectivity; polysulfone
Director R and D Office, Ottawa; Bureau du directeur R-D, Ottawa
Polysulfones with three types of alanyl residue, such as N-α-acetylalanine (Ac-Ala-OH), N-α-benzoylalanine (Bzo-Ala-OH), and N-α-benzyloxycarbonylalanine (Z-Ala-OH), as chiralselectors were prepared by polymer reaction. The resulting modified polysulfones showed chiroptical properties, indicating that the chiralselector residues were successfully introduced into the polysulfone. Nanofibermembranes prepared from the polymeric materials showed adsorption selectivity toward mixtures of racemic Glu, which were adopted as model racemates. Flux values for the nanofibermembranes were enhanced two to three orders of magnitude in comparison with the corresponding typical membranes, but without reduction in permselectivity. In the present study, it is shown that nanofiber is a suitable membrane form not only for molecularly imprinted membranes, but it exhibits enhanced throughput in comparison with typical dense membranes without concurrent reduction in permselectivity.
Full text available on September 10, 2014