Electrospun nanofiber membranes from polysulfones with chiral selector aimed for optical resolution
; Mizushima, Hiroaki
; Yoshikawa, Yoshikawa
; Li, Nanwen
; Robertson, Gilles P.
Guiver, Michael D.
Energy, Mining and Environment; National Research Council Canada; NRC Institute for Chemical Process and Environmental Technology
Autumn Symposium of the Society of Polymer Science, Sept. 19, 2012, Nagoya, Japan
Chiral separation; Electrospray deposition; Membrane; Naofiber fabric; Optical resolution; Permselectivity; Polysulfone
Polysulfones with three types of alanyl residue, such as N-!-acetylalanine (Ac-Ala-OH),
N-!-benzoylalanine (Bzo-Ala-OH), and N-!-benzyloxycarbonylalanine (Z-Ala-OH), as chiral selectors
were prepared by polymer reaction. The resulting modified polysulfones showed chiroptical properties,
indicating that the chiral selector residues were successfully introduced into the polysulfone. Nanofiber
membranes prepared from the polymeric materials showed adsorption selectivity toward mixtures of
racemic Glu, which were adopted as model racemates. Flux values for the nanofiber membranes were
enhanced two to three orders of magnitude in comparison with the corresponding typical membranes, but
without reduction in permselectivity. In the present study, it is shown that nanofiber is a suitable
membrane form not only for molecularly imprinted membranes, but it exhibits enhanced throughput in
comparison with typical dense membranes without concurrent reduction in permselectivity.