Mouse models of Acinetobacter baumannii infection

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DOIResolve DOI: http://doi.org/10.1002/cpmc.36
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TypeArticle
Journal titleCurrent Protocols in Microbiology
ISSN1934-8533
Volume46
Pages6G.3.16G.3.23
Subjectacinetobacter; animal models; mouse; pneumonia; sepsis
AbstractThis unit describes basic protocols for infecting mice through intranasal and intraperitoneal routes with Acinetobacter baumannii to induce associated pneumonia and sepsis, the two most common manifestations of clinical infections with this pathogen. By selecting the appropriate protocols and bacterial strains of different virulence, these mouse models provide an opportunity to study the infection pathogenesis and host-immune responses, and to evaluate the efficacies of prophylactic and therapeutic anti-A. baumannii candidates.
Publication date
PublisherJohn Wiley & Sons, Inc.
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
NPARC number23002131
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Record identifier15f3df3c-44dc-46ff-8f91-ac72bda25253
Record created2017-08-24
Record modified2017-08-24
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