Part 3. A Novel Stereocontrolled, In Situ, Solution- and Solid-Phase, Aza Michael Approach for High-Throughput Generation of Tetrahydroaminoquinoline-Derived Natural-Product-like Architectures

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DOIResolve DOI: http://doi.org/10.1021/cc060059n
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TypeArticle
Journal titleJournal of Combinatorial Chemistry
ISSN1520-4766
Volume8
Issue5
Pages762773; # of pages: 12
AbstractWith the goal of rapidly accessing tetrahydroquinoline-based natural-product-like polycyclic architectures, herein, we report an unprecedented, in situ, stereocontrolled Aza Michael approach in solution and on the solid phase. The mild reaction conditions required to reach the desired target are highly attractive for the use of this method in library generation. To our knowledge, this approach has not been used before, and it opens a novel route leading to a wide variety of tetrahydroquinoline-derived bridged tricyclic derivatives.
Publication date
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier18517171
NPARC number12339184
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Record identifier51f42bf7-9f74-4405-a778-36652c06c3f7
Record created2009-09-11
Record modified2016-05-09
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