Discrimination and quantitation using IR spectra : novel methods for serum analysis and for cervical dysplasia screening

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DOIResolve DOI: http://doi.org/10.1117/12.306091
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TypeBook Chapter
Proceedings titleInfrared Spectroscopy: New Tool in Medicine
Series titleProceedings of SPIE; no. 3257
ConferenceInfrared Spectroscopy: New Tool in Medicine, January 27, 1998, San Jose, California, U. S. A.
ISSN0277-786X
Pages4250; # of pages: 9
Subjectclinical chemistry; partial least squares; Pap smear; glucose; chemometrics; cervical cancer
AbstractIR spectroscopy shows the promise of developing into a clinically relevant methodology for both screening and quantitative applications. The principles are straightforward - the IR spectrum of appropriate biological fluids or tissues may be interpreted to reveal diagnostic information either directly through inspection, or indirectly through the use of appropriate classification or quantitation algorithms. Implementing these methods in practice is not as straightforward. This report summarizes our experiences to date in developing methods for the quantitation of several serum analytes from the IR spectra of dried serum films, and for the IR-based detection/grading of abnormalities in exfoliated cervical cell specimens.
Publication date
PublisherSPIE
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NRC number879
NPARC number9148185
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Record identifier5be420ce-1c2d-4d12-b83d-1228a3c63ec7
Record created2009-06-25
Record modified2017-09-13
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