Anisotropic permeability in deterministic lateral displacement arrays

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TypeArticle
Journal titleFluid Dynamics
Article numberarXiv:1610.08427
Pages# of pages: 9
AbstractWe investigate anisotropic permeability of microfluidic deterministic lateral displacement (DLD) arrays. A DLD array can achieve high-resolution bimodal size-based separation of micro-particles, including bioparticles such as cells. Correct operation requires that the fluid flow remains at a fixed angle with respect to the periodic obstacle array. We show via experiments and lattice-Boltzmann simulations that subtle array design features cause anisotropic permeability. The anisotropy, which indicates the array's intrinsic tendency to induce an undesired lateral pressure gradient, can lead to off-axis flows and therefore local changes in the critical separation size. Thus, particle trajectories can become unpredictable and the device useless for the desired separation duty. We show that for circular posts the rotated-square layout, unlike the parallelogram layout, does not suffer from anisotropy and is the preferred geometry. Furthermore, anisotropy becomes severe for arrays with unequal axial and lateral gaps between obstacle posts and highly asymmetrical post shapes.
Publication date
PublisherCornell University Library
Linkhttps://arxiv.org/abs/1610.08427
LanguageEnglish
AffiliationNational Research Council Canada; Medical Devices
Peer reviewedYes
NPARC number23002041
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Record identifier5e60f1fb-d78c-47b9-8e8f-1a8504d20d90
Record created2017-07-27
Record modified2017-07-27
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