The application of NMR spectroscopy to functional glycomics

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TypeBook Chapter
Book titleFunctional Glycomics
Series titleMethods in Molecular Biology; no. 600
Subjectglycomic; glycans; polysaccharides; glycoanalysis; protein–carbohydrate; interactions; HR-MAS; NMR; structural analysis; molecular modeling
AbstractGlycomics which is the study of saccharides and genes responsible for their formation requires the continuous development of rapid and sensitive methods for the identification of glycan structures. It involves glycoanalysis which relies upon the development of methods for determining the structure and interactions of carbohydrates. For the application of functional glycomics to microbial virulence, carbohydrates and their associated metabolic and carbohydrate processing enzymes and respective genes can be identified and exploited as targets for drug discovery, glyco-engineering, vaccine design, and detection and diagnosis of diseases. Glycomics also encompasses the detailed understanding of carbohydrate–protein interactions and this knowledge can be applied to research efforts focused toward the development of vaccines and immunological therapies to alleviate infectious diseases.
Publication date
AffiliationNational Research Council Canada; NRC Institute for Biological Sciences
Peer reviewedYes
NPARC number23002069
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Record identifier62137941-28b6-4bfc-a20e-f33793e6aaad
Record created2017-08-04
Record modified2017-08-04
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