Beware of connective tissue proteins : assignment and implications of collagen absorptions in infrared spectra of human tissues

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DOIResolve DOI: http://doi.org/10.1016/0925-4439(94)00056-V
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TypeArticle
Journal titleBiochimica et Biophysica Acta
ISSN0925-4439
Volume1270
Issue1
Pages16; # of pages: 6
SubjectHuman tissue; MR; Collagen; Connective tissue; Cancer
AbstractInfrared spectra of human central nervous system tissue and human breast carcinoma are presented. The spectra are discussed in terms of the composition of the tissues. It is shown that differences between spectra of white and grey matter can be rationalised on the basis of differences in lipid content. Spectra of the choroid plexus and arachnoid villus of the meninges show a series of absorptions not observed in other CNS tissue. These absorptions are discussed in terms of the connective tissue content of the samples. We demonstrate that the presence of collagen results in the appearance of a series of characteristic absorptions which may be mis-assigned as DNA phosphate absorptions. The implications of the presence of collagen in tissues for the diagnosis of disease states by IR spectroscopic methods, with particular reference to cancer, is discussed.
Publication date
PublisherElsevier Science B.V.
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biodiagnostics
Peer reviewedYes
NRC number302
NPARC number9742654
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Record identifier62be885b-b19a-4190-b433-d9ab5ddce9e1
Record created2009-07-17
Record modified2016-12-02
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