Quantitative high-throughput analysis of domoic acid in mussel tissue homogenates using laser ablation electrospray ionization – MS/MS

  1. (PDF, 615 KB)
AuthorSearch for: ; Search for: ; Search for:
Conference30th Montreaux LC/MS Symposium, 3–7 November 2014, Charleston, USA
AbstractWe investigated the use of Laser Ablation Electrospray Ionization (LAESI) with MS/MS detection for Domoic Acid (DA) analysis directly from mussel tissue homogenates without sample extraction, cleanup or chromatographic separation. DA could be selectively detected directly from mussel tissue homogenates using LAESI-MS/MS in selected reaction monitoring scan mode. A matrix matched calibration curve was used to quantify mussel tissue reference materials and results were in good agreement with two established methods, LC-UV and LC-MS/MS, within the linear range. Most notable is the decrease in run time from about 20 minutes for a typical chromatographic method to about 10 seconds per sample for LAESI-MS/MS.
Publication date
AffiliationNational Research Council Canada; Measurement Science and Standards
Peer reviewedYes
NPARC number23002022
Export citationExport as RIS
Report a correctionReport a correction
Record identifier8a18e683-ac07-4502-a1f5-e6d97c095119
Record created2017-07-21
Record modified2017-07-25
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)