Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes

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DOIResolve DOI: http://doi.org/10.1038/srep04549
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TypeArticle
Journal titleScientific Reports
ISSN2045-2322
Volume4
Article number4549
AbstractHepatitis C virus (HCV) replication is dependent on the formation of specialized membrane structures; however, the host factor requirements for the formation of these HCV complexes remain unclear. Herein, we demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis of unsaturated fatty acids, such as oleic acid, and negatively modulates HCV replication. Unsaturated fatty acids play key roles in membrane curvature and fluidity. Mechanistically, we demonstrate that SCD-1 inhibition disrupts the integrity of membranous HCV replication complexes and renders HCV RNA susceptible to nuclease-mediated degradation. Our work establishes a novel function for unsaturated fatty acids in HCV replication.
Publication date
PublisherNature Publishing Group
LanguageEnglish
AffiliationNational Research Council Canada; Medical Devices; Security and Disruptive Technologies
Peer reviewedYes
NPARC number21272642
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Record identifier9cdcf4c8-7f8d-4413-8b2c-bfcc0e220b6f
Record created2014-12-03
Record modified2016-05-09
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