Determination of total mercury in biological tissue by isotope dilution ICPMS after UV photochemical vapor generation

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DOIResolve DOI: http://doi.org/10.1016/j.talanta.2013.09.024
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TypeArticle
Journal titleTalanta
ISSN0039-9140
Volume117
Pages371375; # of pages: 5
SubjectBiological samples; Certified reference materials; Chemical vapor generation; External calibration; Isotope dilution inductively coupled plasma mass spectrometry; Isotope dilutions; Pneumatic nebulization; Sample preparation procedure; Formic acid; Inductively coupled plasma; Inductively coupled plasma mass spectrometry; Isotopes; Mass spectrometry; Mercury (metal); Vapors; Tissue
AbstractA method is developed for the determination of trace mercury in biological samples using photo chemical vapor generation (PVG) and isotope dilution inductively coupled plasma mass spectrometry (ID ICPMS) detection. Biological tissues were solubilized in formic acid. Subsequently, the sample solutions were exposed to an ultraviolet (UV) source for the reduction of mercury into vapor species prior to ICPMS measurements. The formic acid served not only as a tissue solubilizer in the sample preparation procedure, but also as a photochemical reductant for mercury in the PVG process. The problem arising from the opaque formic acid digested solution was efficiently solved by using ID method. The optimum conditions for sample treatment and PVG were investigated. A limit of detection (LOD) of 0.5 pg g-1, based on an external calibration, provided 350-fold improvement over that obtained by utilizing conventional pneumatic nebulization sample introduction. Method validation was demonstrated by the determination of total mercury in several biological tissue certified reference materials (CRMs). The results were in good agreement with the certified values. © 2013 Elsevier B.V. All rights reserved.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270602
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Record identifiera7824315-623b-42c8-839a-3c2b608fb93f
Record created2014-02-17
Record modified2016-05-09
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