A medically relevant capsular polysaccharide in Acinetobacter baumannii is a potential vaccine candidate

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DOIResolve DOI: http://doi.org/10.1016/j.vaccine.2017.01.060
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TypeArticle
Journal titleVaccine
ISSN0264-410X
Volume35
Issue10
Pages14401447
SubjectAcinetobacter baumannii; capsular polysaccharide; passive immunity; clinic population distribution
AbstractConcerns of Acinetobacter baumannii infection have increased due to the emergence of multi-drug resistance. In the present study, we determined the capsular polysaccharide (CPS) structure of A. baumannii SK44, a clinical isolate from Taiwan, to consist of pentasaccharide repeats. We found that CPS-induced antibody provided 55% protection against challenge in an animal model. The CPS-specific antibody reacted with the surface components of about 62% clinical isolates (342/554 strains) from cross-sectional and longitudinal studies by dot-immunoassay. Pulsed-field gel electrophoresis of positive strains showed the antibody covered different clonalites of A. baumannii clinical isolates. Meanwhile, using the CPS antibody as a probe, we found a number of outer membrane proteins bound to the antibody, including OmpA/motB, TonB-dependent receptor, and Omp38, indicating their association with CPS. These results might lead to the use of the capsular polysaccharide as a vaccine to prevent A. baumannii infection.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
NPARC number23002573
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Record identifierb8e2a538-a934-4285-a29d-c32aecde4296
Record created2017-11-30
Record modified2017-11-30
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