The neuronal primary cilium : Driver of neurogenesis and memory formation in the hippocampal dentate gyrus?

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DOIResolve DOI: http://doi.org/10.1016/j.cellsig.2009.02.013
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TypeArticle
Journal titleCellular Signalling
Volume21
Issue9
Pages13511355; # of pages: 5
SubjectaNSCs (adult neuronal stem cells); astrocytes; Canada; dentate gyrus; dynein; Gli (glioma tumor factor); granule cell; kinesin; molecular; IFT; intraflagellar transport; LTP (long-term potentiation); Primary (solitary) cilium; Ptc (patched); Shh (sonic hedgehog); Smo (smoothened)
AbstractConsiderable attention has recently been focused on the postnatal persistence of neurogenesis in the dentate gyrus of the hippocampus and the roles of signals from the primary cilium in the different functions of an increasing number of tissues and their malfunctions. Here we summarize the evidence that ties sonic hedgehog-triggered proliferogenic signaling from the primary cilia on granule cell progenitors in the adult dentate subgranular zone to maintain a pool of new “blank slate” dentate granule cells. These can be recruited to bundle and encode novel inputs flowing from various regions of the brain into the dentate gyrus via the entorhinal cortex without altering and erasing the synaptic patterns from previous inputs inscribed on older granule cells.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Biological Sciences
Peer reviewedYes
NRC numberWHITFIELD2009A
NPARC number15329253
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Record identifierd1cfa2d2-b5b6-4376-bcb2-e0ebf7fd5c83
Record created2010-05-21
Record modified2016-05-09
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