Developing trends in aptamer-based biosensor devices and their applications

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DOIResolve DOI: http://doi.org/10.1109/TBCAS.2014.2304718
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TypeArticle
Journal titleIEEE Transactions on Biomedical Circuits and Systems
ISSN1932-4545
Volume8
Issue1
Article number6744673
Pages414; # of pages: 11
SubjectAntibodies; Carbon nanotubes; Chemical detection; RNA; Aptamers; Biomolecular recognition; ELectrochemical detection; Environmental Monitoring; Optical detection; SELEX; Sensing applications; Single-stranded DNA; Biosensors
AbstractAptamers are, in general, easier to produce, easier to store and are able to bind to a wider variety of targets than antibodies. For these reasons, aptamers are gaining increasing popularity in environmental monitoring as well as disease detection and disease management applications. This review article examines the research and design of RNA and DNA aptamer based biosensor systems and applications as well as their potential for integration in effective biosensor devices. As single stranded DNA or RNA molecules that can bind to specific targets, aptamers are well suited for biomolecular recognition and sensing applications. Beyond being able to be designed for a near endless number of specific targets, aptamers can also be made which change their conformation in a predictable and consistent way upon binding. This can lead to many unique and effective detection methods using a variety of optical and electrochemical means. © 2007-2012 IEEE.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); National Institute for Nanotechnology (NINT-INNT)
Peer reviewedYes
NPARC number21272124
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Record identifierec08a1c0-bf09-4a33-98a4-8a0826acc3f8
Record created2014-07-23
Record modified2016-05-09
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