Appetite regulation and weight control : the role of gut hormones

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Journal titleNutrition and Diabetes
Subjectobesity; appetite; hypothalamus; gut hormones
AbstractThe overwhelming increase in the prevalence of overweight and obesity in recent years represents one of the greatest threats to the health of the developed world. Among current treatments, however, gastrointestinal (GI) surgery remains the only approach capable of achieving significant weight loss results with long-term sustainability. As the obesity prevalence approaches epidemic proportions, the necessity to unravel the mechanisms regulating appetite control has garnered significant attention. It is well known that physical activity and food intake regulation are the two most important factors involved in body weight control. To regulate food intake, the brain must alter appetite. With this realization has come increased efforts to understand the intricate interplay between gut hormones and the central nervous system, and the role of these peptides in food intake regulation through appetite modulation. This review discusses the central mechanisms involved in body weight regulation and explores a suite of well characterized and intensely investigated anorexigenic and orexigenic gut hormones. Their appetite-regulating capabilities, post-GI surgery physiology and emerging potential as anti-obesity therapeutics are then reviewed.
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AffiliationNRC Institute for Nutrisciences and Health; National Research Council Canada
Peer reviewedYes
NRC number54685
NPARC number19547523
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Record identifierfca2469a-6cd0-4fe5-86ee-2601c95447bf
Record created2012-02-23
Record modified2016-05-09
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